主持项目：

1、神经肽S的构效关系及其胃肠道生理活性研究（30600094）。国家自然科学基金委。

2、新的神经肽系统在焦虑与抑郁疾病中作用机理的研究。甘肃省科技厅。

3、校企合作项目

承担本科生《生物化学》、《动物生理学》、《多肽科学》、《生物学文献检索》、《人体解剖生理学》、《动物生理学实验》课程。

硕士生导师。

1、神经肽的高级神经功能作用

2、多肽药物

3、功能性多肽应用

1、常民，首届兰州大学隆基青年教师教学新秀奖。

2、陈强，董守良，常民，甘肃省精品课程《动物生理学》。

3、陈强，董守良，常民，教育部双语教学示范课程《动物生理学》。

4、Li W, Gao YH, Chang M, Peng YL, Yao J, Han RW, Wang R. Gayle and Richard Olson Prize for Most Outstanding Behavioral Paper Published the Previous Year in the Journal Peptides, 2010.

5、《多肽新药研发的化学修饰的专利技术》，甘肃省技术发明一等奖，排名第五。

6、《多肽药物的规模化和机械化制备技术创新及应用》，教育部科技进步奖一等奖，排名第四。

发明专利：

1. Li S, Guo C, Zhang XJ, Liu XJ, Mu J, Liu CX, Peng YL, Chang M*. Self-assembling modified neuropeptide S enhances nose-to-brain penetration and exerts a prolonged anxiolytic-like effect. Biomater Sci, 2021, doi: 10.1039/D1BM00380A.
2. Jiang JH, Chang X, Nie YY, Shen YX, Liang XY, Peng YL, Chang M*. Peripheral Administration of a Cell-Penetrating MOTS-c Analogue Enhances Memory and Attenuates Aβ1-42- or LPS-Induced Memory Impairment through Inhibiting Neuroinflammation. ACS Chem Neurosci. 2021;12(9):1506-1518.
3. Li S, Zhang XJ, Guo C, Peng YL, Wang B, Zhuang R, Chang M*, Wang R*. Hydrocarbon staple constructing highly efficient α-helix cell-penetrating peptides for intracellular cargo delivery. Chem Commun. 2020;56(100):15655-15658.
4. Xue, HX, Guo, MZ, Wang, C, Shen, YX, Qi, RP, Wu, YF, Xu, ZQ*, Chang M*. Photo-induced preparation of unnatural alpha-amino acids: synthesis and characterization of novel Leu(5)-enkephalin analogues. Org Chem Front.2020;7(17):2426-2431
5. Wang C, Qi RP, Xue HX, Shen YX, Chang M, Chen Y, Wang R, Xu ZQ*. Visible-Light-Promoted C(sp3)-H Alkylation by Intermolecular Charge Transfer: Preparation of Unnatural α-Amino Acids and Late-Stage Modification of Peptides. Angew Chem Int Ed Engl. 2020;59(19):7461-7466.
6. Jiang JH, Wang Z, Liang XY, Nie Y, Chang X, Xue HX, Li S, Chang M*. Intranasal MMI-0100 Attenuates Aβ1-42- and LPS-Induced Neuroinflammation and Memory Impairments via the MK2 Signaling Pathway. Front Immunol. 2019;10:2707.
7. Jiang JH, Jin W, Peng Y, Liang X, Li S, Wei L, Lei Z, Li L, Chang M*. The role of Cortistatin-14 in the gastrointestinal motility in mice. Pharmacol Rep. 2018;70(2):355-363.
8. Jiang J, Peng Y, Liang X, Li S, Chang X, Li L, Chang M*. Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via Mediating Ghrelin and GABAA Receptor Signaling Pathway. Front Pharmacol. 2018;9:767.
9. Jiang JH, Peng YL, Zhang PJ, Xue HX, He Z, Liang XY, Chang M*. The ventromedial hypothalamic nucleus plays an important role in anxiolytic-like effect of neuropeptide S. Neuropeptides. 2017;67:36-44.
10. Jiang JH, Peng YL, He Z, Wei LJ, Jin WD, Wang XL, Chang M*. Intrahippocampal injection of Cortistatin-14 impairs recognition memory consolidation in mice through activation of sst2, ghrelin and GABAA/B receptors. Brain Res. 2017;1666:38-47.
11. Jiang JH, Jin WD, Peng YL, He Z, Wei LJ, Li S, Wang XL, Chang M*, Wang R*. In vivo and vitro characterization of the effects of kisspeptin-13, endogenous ligands for GPR54, on mouse gastrointestinal motility. Eur J Pharmacol. 2017;794:216-223.
12. Jiang JH, He Z, Peng YL, Jin WD, Wang Z, Mu LY, Chang M*, Wang R*. Phoenixin-14 enhances memory and mitigates memory impairment induced by Aβ1-42 and scopolamine in mice. Brain Res. 2015;1629:298-308.
13. Li MS, Peng YL, Jiang JH, Xue HX, Wang P, Zhang PJ, Han RW, Chang M*, Wang R*. Neuropeptide S Increases locomotion activity through corticotropin-releasing factor receptor 1 in substantia nigra of mice. Peptides. 2015 Jul 31;71:196-201.
14. Jiang JH, He Z, Peng YL, Jin WD, Wang Z, Han RW, Chang M*, Wang R*. Kisspeptin-13 enhances memory and mitigates memory impairment induced by Aβ1-42 in mice novel object and object location recognition tasks. Neurobiol Learn Mem. 2015;123:187-95.
15. Jiang JH, He Z, Peng YL, Jin WD, Mu J, Xue HX, Wang Z, Chang M*, Wang R*. Effects of Phoenixin-14 on anxiolytic-like behavior in mice. Behav Brain Res. 2015;286:39-48.
16. Han RW, Xu HJ, Zhang RS, Wang P, Chang M, Peng YL, Deng KY, Wang R*. Neuropeptide S interacts with the basolateral amygdala noradrenergic system in facilitating object recognition memory consolidation. Neurobiol Learn Mem. 2014 ;107:32-6.
17. Zhong Y, Ma SX , Xu ZQ, Chang M, Wang R*. Organocatalytic asymmetric vinylogous Michael addition of 3-alkylidene oxindoles to alpha-substituted beta-nitroacrylates: facile construction of a chiral all-carbon quaternary center. RSC Advances, 2014;4(91):49930-3.
18. Ma SX, Zhong Y, Wang SL, Xu ZQ, Chang M, Wang R*. Organocatalyzed Asymmetric Allylic Alkylation of MBH-Carbonates with Pyrazolone. Acta Chimica Sinica, 2014;72(7):825-9
19. Han, RW, Zhang RS, Xu HJ, Chang M, Peng YL, Wang R*. Neuropeptide S enhances memory and mitigates memory impairment induced by MK801, scopolamine or Abeta42 in mice novel object and object location recognition tasks, Neuropharmacology, 2013;70:261-7.
20. Han RW, Zhang RS, Chang M, Peng YL, Wang P, Hu SQ, Choi CL, Yin M, Wang R*, Han YF. Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins. Brain Res. 2012;1470:59-68.
21. Peng YL, Zhang JN, Chang M, Li W, Han RW, Wang R*. Effects of central neuropeptide S in the mouse formalin test. Peptides. 2010;31(10):1878-83.
22. Peng YL, Han RW, Chang M, Zhang L, Zhang RS, Li W, Han YF, Wang R*. Central Neuropeptide S inhibits food intake in mice through activation of Neuropeptide S receptor. Peptides. 2010;31(12):2259-63.
23. Chang M, Li W, Peng YL, Gao YH, Yao J, Han RW, Wang R*. Involvement of NMDA receptor in nociceptive effects elicited by intrathecal [Tyr6]γ2-MSH(6-12), and the interaction with nociceptin/orphanin FQ in pain modulation in mice. Brain Res. 2009;1271:36-48.
24. Li W, Chang M, Peng YL, Gao YH, Zhang JN, Han RW, Wang R*. Neuropeptide S produces antinociceptive effect at the supraspinal level in mice. Regul. Pept. 2009;156:90-5.
25. Han RW, Chang M, Peng YL, Qiao LY, Yin XQ, Li W, Wang R*. Central Neuropeptide S inhibits distal colonic transit through activation of central Neuropeptide S receptor in mice. Peptides. 2009;30(7): 1313-17.
26. Han RW, Yin XQ, Chang M, Peng YL, Li W, Wang R*. Neuropeptide S facilitates spatial memory and mitigates spatial memory impairment in mice morris water maze. Neuro. Lett. 2009;455:74-7.
27. Li W, Gao YH, Chang M, Peng YL, Yao J, Han RW, Wang R*. Neuropeptide S inhibits the acquisition and the expression of conditioned place preference to morphine in mice. Peptides. 2009;30(2):234-40.
28. Chen ZX, Chang M, Peng YL, Zhao L, Zhan YR, Wang LJ, Wang R*. Regulation of Endochondral Ossification by Osteogenic Growth Peptide C-terminal Pentapeptide [OGP(10-14)]. Protein Pept. Lett. 2009;16:1074-80.
29. 常民, 彭雅丽, 李威, 王锐. 神经肽S的功能与构效关系研究进展. 生物物理学报. 2009;03:175-82.
30. 常民, 李威, 王锐. Mrg受体家族的研究进展. 中国药理学通报. 2009;07:841-44.
31. Li Z, Zhou LX, Zhang BH, Yan X, Li J, Peng YL, Chang M, Dong SL, Wang R*. Effect and mechanism of nociceptin/orphanin FQ reversing multi-drug resistance in K562/ADM cell. Pharmazie. 2008;63(9):676-85.
32. Chen ZX, Chang M, Peng YL, Zhao L, Zhan YR, Wang LJ, Wang R*. Osteogenic growth peptide C-terminal pentapeptide [OGP(10-14)] acts on rat bone marrow mesenchymal stem cells to promote differentiation to osteoblasts and to inhibit differentiation to adipocytes. Regul Pept. 2007;142(1-2):16-23.
33. Peng YL, Chang M, Dong SL, Li W, Han RW, Fu GX, Chen Q, Wang R*. Novel potent agonist [(pF)Phe4,Aib7,Aib11,Arg14,Lys15]N/OFQ-NH2 and antagonist [Nphe1,(pF)Phe4, Aib7,Aib11,Arg14,Lys15]N/OFQ-NH2 of nociceptin/orphanin FQ receptor. Regul. Pept. 2006;134:75-81. (共同第一作者)
34. Fang Q, Guo J, Peng YL, Chang M, He F, Chen Q, Wang R*. In vitro and in vivo studies of dansylated compounds, the putative agonists and antagonists on neuropeptide FF receptors. Peptides. 2006;27:1297-304.
35. Yang Q, Chen Y, Fu C, Chang M, Peng YL, Wang R*. Effects of [Nphe1]nociceptin(1-13)NH2, [Phe1(CH2-NH)Gly2]nociceptin(1- 13)NH2, and nocistatin on nociceptin inhibited constrictions of guinea pig isolated bronchus. Protein Pept Lett. 2006;13(2):185-8.
36. Fang Q, Guo J, He F, Peng YL, Chang M, Wang R. In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonist. Peptides. 2006;27:2207-13.
37. Fang Q, Guo J, Chang M, Chen LX, Chen Q, Wang R*. Neuropeptide FF receptors exert contractile activity via inhibition of nitric oxide release in the mouse distal colon. Peptides. 2005;26(5):791-7.
38. Chang M, Peng YL, Dong SL, Han RW, Li W, Yang DJ, Chen Q, Wang R*. Structure-activity studies on different modifications of nociceptin/orphanin FQ: identification of highly potent agonists and antagonists of its receptor. Regul. Pept. 2005;130:116-22.
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